Yonghua Sun

Ultra-fast genetic recovery of dead fish through cross-family germline stem cell transplantation

This study demonstrates an ultra-fast genetic recovery method using cross-species germline stem cell transplantation to revive dead fish, producing viable offspring within three months.

Engineering Treg-mediated immune tolerance via foxp3a overexpression to evade allograft transplantation barriers in zebrafish

This paper demonstrates that overexpressing Foxp3a in zebrafish induces Treg-mediated immune tolerance, enabling efficient transplantation of gonadal primordia and germline stem cells.

Assessment of fish spermatogenesis through high-quality immunofluorescence against fish testicular samples with an antibody set

The paper develops antibodies and an immunofluorescence method to accurately identify spermatogenic cell types in fish testis samples across multiple species.

Translation control by maternal Nanog promotes oocyte maturation and early embryonic development

This study shows maternal Nanog controls oocyte maturation and early embryonic development by repressing eef1a1l2 transcription, which reduces translational activity and prevents ER stress.

A landscape of differentiated biological processes involved in the initiation of sex differentiation in zebrafish

This study identifies distinct biological processes in zebrafish gonad differentiation at 25 and 30 dpf, revealing metabolic and immune-related pathways in ovary and testis development respectively.

Cilia regulate meiotic recombination in zebrafish

This study shows that cilia regulate meiotic recombination in zebrafish by affecting double strand break repair, crossover formation, and germ cell survival.

Surrogate production of genome edited sperm from a different subfamily by spermatogonial stem cell transplantation

This study demonstrates the successful production of genome-edited sperm from a phylogenetically distant fish species using cross-subfamily spermatogonial stem cell transplantation.

Elovl2 but not Elovl5 is essential for the biosynthesis of docosahexaenoic acid (DHA) in zebrafish: insight from a comparative gene knockout study

This study shows Elovl2, not Elovl5, is essential for DHA synthesis in zebrafish, using gene knockout models and quantifying DHA levels in liver and embryos.

Nanog safeguards early embryogenesis against global activation of maternal β-catenin activity by interfering with TCF factors

This study shows Nanog represses maternal β-catenin activity by interfering with TCF factors, preventing hyper-dorsalization in early embryos.

Efficient generation of zebrafish maternal-zygotic mutants through transplantation of ectopically induced and Cas9/gRNA targeted PGCs

This study develops a method combining CRISPR/Cas9 and PGC transplantation to efficiently generate maternal-zygotic mutants of embryonic lethal genes in zebrafish.

The allotetraploid origin and asymmetrical genome evolution of common carp Cyprinus carpio

This study investigates the allotetraploid origin and genome evolution of common carp by analyzing new reference genomes and identifying subgenome expression bias and methylation patterns.