DNA binding and lesion recognition by the bacterial interstrand DNA crosslink glycosylase AlkX
Yujuan Cai, Dillon E. Kunkle, Marcel D. Edinbugh, Noah P Bradley, Eric Patrick Skaar, Brandt F. Eichman
This study identifies key motifs in AlkX critical for ICL repair and shows a genetic variant reduces its activity, increasing bacterial sensitivity to DNA crosslinking.
EMBO Reports · May 8, 2026Peer-reviewedBiochemistry