Author

Noah P Bradley

Vanderbilt UniversityORCID 0000-0002-2701-3405Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Brandt F. EichmaniD· 2 shared Antonis RokasiD· 1 shared Dillon E. KunkleiD· 1 shared Eric Patrick SkaariD· 1 shared Jacob Lucas SteenwykiD· 1 shared Katherine L. WahliD· 1 shared Marcel D. EdinbughiD· 1 shared Yujuan CaiiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 16 mutual co-author links

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2 shared papersBiochemistry

Brandt F. EichmanORCID

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2 papers

Recent·Most cited

DNA binding and lesion recognition by the bacterial interstrand DNA crosslink glycosylase AlkX

Yujuan Cai, Dillon E. Kunkle, Marcel D. Edinbugh, Noah P Bradley, Eric Patrick Skaar, Brandt F. Eichman

This study identifies key motifs in AlkX critical for ICL repair and shows a genetic variant reduces its activity, increasing bacterial sensitivity to DNA crosslinking.

EMBO Reports · May 8, 2026Peer-reviewedBiochemistry

Resistance-guided mining of bacterial genotoxins defines a family of DNA glycosylases

Noah P. Bradley, Katherine L. Wahl, Jacob Lucas Steenwyk, Antonis Rokas, Brandt F. Eichman

The paper identifies AlkZ and AlkX DNA glycosylases involved in bacterial resistance to genotoxins, linking them to specific antimicrobial production.

mBio · Mar 21, 2022Peer-reviewedMolecular Biology