Machine learning-guided directed evolution for the development of small-molecule antibiotics originating from antimicrobial peptides
Heqian Zhang, Yihan Wang, Pengtao Huang, Yanran Zhu, Xiaojie Li, Zhaoying Chen, Yu Liu, Jiakun Jiang, Yuan Gao, Jiaquan Huang, Zhiwei Qin
This study uses machine learning-guided directed evolution to develop a peptide antibiotic from antimicrobial peptides, showing improved antimicrobial activity and therapeutic potential.
bioRxiv · Nov 3, 2022 · PreprintSynthetic Biology