Yu Liu

Apolipoprotein E4 Exacerbates Aβ Oligomer-Induced Synaptotoxicity through Promoting Autophagic Degradation of Glutathione Peroxidase 4

This study shows APOE4 worsens Aβ oligomer-induced synaptotoxicity by promoting autophagic degradation of STIM1 and Gpx4, leading to mitochondrial dysfunction and synaptic loss.

Effects of Alternating Polarity Frequency on the Assembly of Electro-Methanogenic Microbial Communities

This study evaluates how alternating polarity frequency affects the assembly of electro-methanogenic microbial communities, finding that 4-day alternation yields the best performance.

FLASH X-rays preserve neutrophil chromatin to boost antitumor immunity

This study shows FLASH X-rays preserve neutrophil chromatin, reducing NET formation and enhancing antitumor immunity when combined with anti-PD-1 therapy.

ECC-MR: an error-correcting-code framework for robust Mendelian randomization and pleiotropy decoding on correlated instruments

ECC-MR improves Mendelian randomization by using error-correcting code principles to handle pleiotropy and linkage disequilibrium, providing more accurate causal estimates.

Plasma proteomics reveal heterogeneous subtypes of depression linked to inflammation and aging

The paper identifies three depression subtypes using plasma proteomics, linked to inflammation, aging, and metabolic factors, with distinct clinical and neurobiological features.

Reactivation of a TAL1 progenitor cell enhancer region by non-coding somatic variants in T-lineage acute lymphoblastic leukemia

The paper identifies non-coding somatic variants in TAL1 regulatory regions that reactivate enhancers normally active in hematopoietic stem cells in T-lineage acute lymphoblastic leukemia.

A morphometric approach to the taxonomic dilemma of Zonozoe drabowiensis Barrande, 1872 and Zonoscutum solum Chlupá&ccaron, 1999 (Upper Ordovician, Czech Republic)

This study uses morphometric analysis to resolve a long-standing taxonomic debate about two Upper Ordovician arthropods, placing them within Vicissicaudata.

Disrupted dynamics of brain structure function coupling link genetic risk of Alzheimer's Disease and aging to cognitive decline in 34,067 adults

The paper examines how static and dynamic structure-function coupling in the brain relates to cognitive decline and Alzheimer's risk in 34,067 adults.

High-pressure Golgi neuronal staining for X-ray whole-brain imaging

This paper introduces a rapid high-pressure Golgi staining method for whole-brain neuronal imaging, reducing staining time from 16 days to 4 days and demonstrating applicability across multiple species.

Iterative delivery of mRNA by MEFI

This paper introduces MEFI, a platform for iterative mRNA delivery that enhances expression and cross-organ transfer in mice.

Cerebellar output neurons impair non-motor behaviors by altering development of extracerebellar connectivity

This study shows that ablating cerebellar output neurons has less impact on behavior than genetic mutations in these neurons, which cause additional deficits in learning and memory.

Genome sequencing of 'Fuji' apple clonal varieties reveals evolutionary history and genetic mechanism of the spur-type morphology

The paper sequenced clonal Fuji apple varieties to uncover somatic variants linked to spur-type morphology and early maturation traits.

The cerebellum contributes to tonic-clonic seizures by altering neuronal activity in the ventral posteromedial nucleus (VPM) of the thalamus

This study identifies the ventral posteromedial nucleus of the thalamus as a source of tonic-clonic seizures, showing cerebellar input drives seizure initiation.

Genome-wide Association study of facial morphology identifies novel genetic loci in Han Chinese

This study identifies five novel genetic loci associated with facial morphology traits in Han Chinese through a genome-wide association analysis of 3D facial data.

Causal evidence for a cerebellar role in prefrontal-hippocampal interaction in spatial working memory decision-making

This study shows that cerebellar stimulation impairs spatial working memory and disrupts mPFC-dCA1 coherence, suggesting a role for the cerebellum in modulating prefrontal-hippocampal interactions during decision-making.

Apigenin relaxes rat intrarenal arteries: involvement of Cl- channels and K+ channels

This study shows apigenin relaxes rat intrarenal arteries by modulating Cl- and K+ channels, with effects mediated through CaCCs and Kv channels.

Skeletal Muscle Metrics on Clinical 18F- FDG PET/CT Predict Health Outcomes in Patients with Sarcoma

This study links skeletal muscle metrics from 18F-FDG PET/CT to health outcomes and serum biomarkers in sarcoma patients, finding associations with survival and complications.

Structural basis of transcription inhibition by fidaxomicin (lipiarmycin A3)

This paper reports the cryo-EM structure of Mycobacterium tuberculosis RNAP holoenzyme bound to fidaxomicin, revealing its unique binding site and mechanism of transcription inhibition.

Cerebellar Purkinje cell simple spike activity in awake mice represents phase differences between oscillations in medial prefrontal cortex and hippocampus

The paper shows that cerebellar Purkinje cells in awake mice encode phase differences between oscillations in the medial prefrontal cortex and hippocampus during spatial working memory tasks.

Thalamocortical transmission of visual information in awake mice involves phase synchronization and spike synchrony at high gamma frequencies

This study shows that high gamma oscillations (50-90Hz) mediate phase synchronization and spike synchrony between thalamus and cortex in awake mice during visual processing.

VCF2CNA: A tool for efficiently detecting copy-number alteration in VCF genotype data

VCF2CNA detects copy-number alterations from VCF data with high accuracy and platform independence, outperforming existing methods in neuroblastoma samples.

Incidental identification of maternal malignancies in two Asian women underwent noninvasive prenatal test

This study reports two cases of maternal malignancies detected incidentally during noninvasive prenatal tests in Asian women, showing concordant genome disruption patterns between tumor samples and NIPT results.

Cortical rhythms are modulated by respiration

This paper reviews evidence linking respiration to cortical oscillations and proposes that respiration modulates cortical rhythms and cognitive functions across mammals.