Repurposing AZD-5991 for inhibiting growth and biofilm formation of Staphylococcus aureus by disrupting the cell membrane and targeting FabI.
Yuanyuan Tang, Han‐Xiang Deng, Zhichao Xu, Zhijian Yu, Yong Xiang, Zewen Wen, Shiqing Han, Zhong Chen, Tieying Hou
This paper shows AZD-5991 inhibits S. aureus growth and biofilm formation by disrupting the cell membrane and targeting FabI, suggesting it as a potential new antibiotic.
BMC Microbiology · Jul 2, 2025Peer-reviewedMicrobiology