Author

Hugo Dorison

Centre National de la Recherche ScientifiqueORCID 0000-0002-1431-062XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Approach:experimental assay· 1 Organism:mouse· 1 Research Focus:protein design· 1 Assay:proteomics· 1

Frequent Co-Authors

Anne-Laure GrindeliD· 1 shared Bernard MaillèreiD· 1 shared Camille Le Drezen· 1 shared Catia OliveiraiD· 1 shared Charles TruilletiD· 1 shared Chloé PluchartiD· 1 shared Francois ThenieriD· 1 shared Gerard MazóniD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperMolecular Biology

Anne-Laure GrindelORCID

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2 papers

Recent·Most cited

Machine Learning-Guided Engineering of High-Affinity Cross-Reactive Antibodies with Minimal Mutations

Hugo Dorison, Anne-Laure Grindel, Francois Thenier, Chloé Pluchart, Mélanie Münch, Catia Oliveira, Steven DuBois, Camille Le Drezen, Raphaël Guérois, Bernard Maillère, Charles Truillet, Hervé Nozach

The paper engineers high-affinity cross-reactive antibodies with minimal mutations using deep learning and deep mutational scanning.

bioRxiv · Jul 16, 2026 · PreprintMolecular Biology

Sumo-mediated recruitment allows timely function of the Yen1 nuclease in mitotic cells

Hugo Dorison, Ibtissam Talhaoui, Gerard Mazón

This study shows that Sumo-mediated recruitment is essential for Yen1 nuclease function in resolving DNA intermediates and maintaining genome stability during mitosis.

PLoS Genetics · Mar 25, 2022Peer-reviewedMolecular Biology