Author

Hervé Nozach

Commissariat à l'Énergie Atomique et aux Énergies AlternativesORCID 0000-0002-4021-5204Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein design· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Alexandra EvagelidisiD· 1 shared Ali Ben Djoudi Ouadda· 1 shared Anne-Laure GrindeliD· 1 shared Annik PratiD· 1 shared Aurélien ThureauiD· 1 shared Bernard MaillèreiD· 1 shared Camille Le Drezen· 1 shared Carole Fruchart‐GaillardiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperMolecular Biology

Alexandra EvagelidisORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintJul 16, 2026

Machine Learning-Guided Engineering of High-Affinity Cross-Reactive Antibodies with Minimal Mutations

Hugo Dorison, Anne-Laure Grindel, Francois Thenier…·Hervé Nozach

The paper engineers high-affinity cross-reactive antibodies with minimal mutations using deep learning and deep mutational scanning.

DOI 10.64898/2026.07.15.738714

mouseproteomics

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Molecular BiologyMolecular MetabolismPeer-reviewedDec 22, 2022

Molecular interactions of PCSK9 with an inhibitory nanobody, CAP1 and HLA-C: functional regulation of LDLR levels

Carole Fruchart‐Gaillard, Ali Ben Djoudi Ouadda, Lidia Ciccone…·Nabil Georges Seidah

This study determines the 3D structure of the PCSK9-CHRD-P1.40 complex and shows how CAP1 and HLA-C interact with PCSK9 to regulate LDLR degradation.

22 citations

humanprotein structure

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