BioengineeringbioRxivPreprint
Analytical and functional clearance of dsRNA contaminants from in vitro transcribed mRNA by an engineered dsRNA-binding protein
Tyson Vonderfecht, Peter Lam, Genia Verovskaya, Jason Potter
This paper identifies dsRNA contaminants in IVT mRNA, shows their functional impact, and introduces B2-S, an engineered protein to clear them, improving mRNA quality and reducing immunostimulatory effects.
DOI 10.64898/2026.09.03.749252