Chronic central-targeted Interleukin-6 overexpression promotes hippocampal and cortical neuropathology in the Tg2576 mouse model of Alzheimer's disease
Carla Canal, Kevin Aguilar, Gemma Comes, Elisenda Sanz, Mercedes Giralt, Paula Sanchís, Juan Hidalgo
This study shows that chronic central IL-6 overexpression in Tg2576 mice worsens amyloidosis-related neuropathology and alters cortical and hippocampal gene expression, with sex-dependent effects.
Alzheimer s Research & Therapy · Jun 9, 2026Peer-reviewedNeuroscience