Paula Sanchís

Chronic central-targeted Interleukin-6 overexpression promotes hippocampal and cortical neuropathology in the Tg2576 mouse model of Alzheimer's disease

This study shows that chronic central IL-6 overexpression in Tg2576 mice worsens amyloidosis-related neuropathology and alters cortical and hippocampal gene expression, with sex-dependent effects.

The intestinal immune response is influenced by nutritional-status and increased physical activity level

This study shows that diet and exercise influence intestinal structure and immune responses, with exercise providing protective effects against acute nutritional stress.

Regular parental exercise before mating influences offspring lower adiposity associated to hypothalamic neurodevelopmental changes

This study shows that parental exercise before mating reduces offspring adiposity and affects hypothalamic gene expression in mice.

The metabolic and molecular mechanisms underlying running-induced energy compensation

This study identifies how running-induced energy compensation occurs through metabolic and molecular mechanisms involving leptin, hypothalamic neurons, and Neuropeptide Y in young mice.

Physical activity promotes gut adaptation, responses to nutrients, and sensitivity to gut peptides

This study shows that physical activity enhances gut adaptations, hormone sensitivity, and appetite regulation, aiding in body weight maintenance.