Haijing Jin

cancerSimCraft simulates cancer genome data at clonal and single-cell resolution, enabling benchmarking of computational methods under varied conditions.

This study benchmarks 11 deconvolution methods on RNA-seq data across 1,766 conditions to identify challenges and guide future tool development.

This study shows that loss of Dnmt3a or MeCP2 in inhibitory neurons leads to distinct but overlapping neurological and molecular effects, with mCH playing a key role in Rett Syndrome pathogenesis.