Loss of Dnmt3a dependent methylation in inhibitory neurons impairs neural function through a mechanism that impacts Rett syndrome
Laura A. Lavery, Kerstin Ure, Ying‐Wooi Wan, Chongyuan Luo, Alexander J. Trostle, Wei Wang, Haijing Jin, Joanna Lopez, Jacinta D. Lucero, Mark A. Durham, Rosa Castanon, Joseph R. Nery, Zhandong Liu, Margaret A. Goodell, Joseph R. Ecker, , Huda Yahya Zoghbi
This study shows that loss of Dnmt3a or MeCP2 in inhibitory neurons leads to distinct but overlapping neurological and molecular effects, with mCH playing a key role in Rett Syndrome pathogenesis.
eLife · Mar 11, 2020Peer-reviewedNeuroscience