Debra Toiber

This study evaluates SIRT6 as an aging biomarker by analyzing transcriptomic data across species and identifies context-dependent dysregulation in Alzheimer's disease.

The paper introduces SPARK-ID, a method to map dynamic DNA damage response interactomes, revealing modular networks coordinated by connector proteins.

This paper develops a reversible SIRT6 deficiency model to study brain aging and neurodegeneration, finding transcriptomic changes resembling aging and Alzheimer's disease.

This study compares 3D genome changes in aging and neurodegenerative mouse models using Hi-C, finding shared early features and distinct later changes linked to DNA damage.

The paper introduces optimalTAD, an algorithm for identifying TADs by maximizing chromatin mark enrichment differences between TADs and boundaries, showing it works across species and cell types.

The paper shows that Tau hyper-acetylation at residue 174 increases its nuclear presence, leading to changes in gene expression and contributing to Alzheimer's disease pathology.