Ekaterina Eremenko

This paper develops a reversible SIRT6 deficiency model to study brain aging and neurodegeneration, finding transcriptomic changes resembling aging and Alzheimer's disease.

This study compares 3D genome changes in aging and neurodegenerative mouse models using Hi-C, finding shared early features and distinct later changes linked to DNA damage.

This study shows CD4 T cells differentiate into cytotoxic T cells in senescent-rich environments, and reducing senescent cells halts this differentiation, impacting aging and disease.

The paper shows that Tau hyper-acetylation at residue 174 increases its nuclear presence, leading to changes in gene expression and contributing to Alzheimer's disease pathology.