Leonie Johanna Lorenz

The paper develops a mathematical model to predict vaccine replacement dynamics in Streptococcus pneumoniae and identifies optimal genomic surveillance strategies.

This study identifies mutations in ilvD, encoding a BCAA biosynthesis protein, as beneficial for pneumococcal survival in blood but detrimental for nasopharyngeal colonization.

The paper introduces a fast clustering tool for bacterial genomes, enabling efficient analysis of millions of genomes and revealing taxonomic insights.