GenomicsNature GeneticsPeer-reviewed
Genome-wide stability of the DNA replication program in single mammalian cells
Saori Takahashi, Hisashi Miura, Takahiro Shibata…·Ichiro Hiratani
This study introduces scRepli-seq, a single-cell DNA replication sequencing method, and shows replication domain organization is conserved in mouse embryonic stem cells, with some cell-to-cell heterogeneity linked to developmental plasticity.
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