Koji Nagao

This study investigates the role of SmcHD1 in forming H3K9me3 blocks on the inactive X chromosome in mice and shows their importance in maintaining stable silencing.

This study identifies de novo CBX1 variants in three individuals with neurodevelopmental features and shows they cause dominant-negative effects by disrupting HP1β chromatin binding.

The paper uses single-cell RNA sequencing and C1 CAGE to identify distinct phases of pluripotency during the naive-to-primed transition in mice.

This study introduces scRepli-seq, a single-cell DNA replication sequencing method, and shows replication domain organization is conserved in mouse embryonic stem cells, with some cell-to-cell heterogeneity linked to developmental plasticity.