Genome-wide stability of the DNA replication program in single mammalian cells
Saori Takahashi, Hisashi Miura, Takahiro Shibata, Koji Nagao, Katsuzumi Okumura, Masato Ogata, Chikashi Obuse, Shin‐ichiro Takebayashi, Ichiro Hiratani
This study introduces scRepli-seq, a single-cell DNA replication sequencing method, and shows replication domain organization is conserved in mouse embryonic stem cells, with some cell-to-cell heterogeneity linked to developmental plasticity.
Nature Genetics · Feb 25, 2019Peer-reviewedGenomics