Multi-omics analyses reveal environmentally adaptive cell-state remodeling during human iPSC biomanufacturing
James Colter, Tiffany Dang, Emilie J. Gysel, Daniel Young, Antoine Dufour, Ian Lewis, Kartikeya Murari, Michael Scott Kallos
The paper shows that biomanufacturing conditions alter molecular states in hiPSCs without losing pluripotency, linking these changes to developmental programs.
bioRxiv · Oct 8, 2026 · PreprintBioengineering