N-acetyl-phenylalanine induces hepatic steatosis in MASLD by disrupting ER-mitochondria calcium coupling and mitochondrial lipid oxidation
Rémy Lefebvre, Theo Rousseaux, Nadia Bendridi, Stéphanie Chanon, Delphine Arquier, Alexandre Humbert, Nicolas Bertocchini, Bruno Pillot, Emmanuelle Meugnier, Aurélie Vieille‐Marchiset, Margaux Nawrot, Claudie Pinteur, Sophie Ayciriex, Rohit Seth Loomba, Jennifer Rieusset, Cyrielle Caussy
This study identifies N-acetyl-phenylalanine (NAPA) as a metabolite that promotes hepatic steatosis in MASLD by disrupting ER-mitochondria calcium coupling and mitochondrial lipid oxidation.
bioRxiv · Sep 24, 2025 · PreprintPathology