Rohit Seth Loomba

N-acetyl-phenylalanine induces hepatic steatosis in MASLD by disrupting ER-mitochondria calcium coupling and mitochondrial lipid oxidation

This study identifies N-acetyl-phenylalanine (NAPA) as a metabolite that promotes hepatic steatosis in MASLD by disrupting ER-mitochondria calcium coupling and mitochondrial lipid oxidation.

Early prediction of liver disease using conventional risk factors and gut microbiome-augmented gradient boosting

This study uses gut microbiome data and machine learning to improve liver disease risk prediction, showing that combining microbiome features with conventional risk factors enhances model performance.

Combined effects of host genetics and diet on human gut microbiota and incident disease in a single population cohort

In 5,959 Finns with genotypes and stool metagenomes, GWAS found 583 independent SNP-taxon associations; dairy intake modified LCT effects on Bifidobacterium, and ABO-linked Faecalicatena lactaris tracked secretor status.

Machine learning enables new insights into clinical significance of and genetic contributions to liver fat accumulation

The paper uses machine learning to quantify liver fat from MRI data and identifies genetic variants associated with liver fat accumulation and related diseases.

Identification of the keystone species in non-alcoholic fatty liver disease by causal inference and dynamic intervention modeling

The paper identifies eight keystone species in NAFLD gut microbiota using causal inference and dynamic intervention modeling, which can restore microbial composition toward a normal state.

MASST: A Web-based Basic Mass Spectrometry Search Tool for Molecules to Search Public Data.

MASST enables querying of public small-molecule tandem MS data to discover molecular relationships in metabolomics and natural product datasets.