NeuroscienceNeuropathology and Applied NeurobiologyPeer-reviewed
SFPQ intron retention, reduced expression and aggregate formation in central nervous system tissue are pathological features of amyotrophic lateral sclerosis
Alison L. Hogan, Natalie Grima, Jennifer A. Fifita…·Ian P. Blair
This study examines SFPQ dysregulation in ALS patients, finding increased intron retention, reduced mRNA expression in motor cortex, and cytoplasmic aggregates.
25 citations