Amy K. Cain

The role of heavy metals in the co-selection of plasmid-borne metal and antibiotic resistance genes from industrially contaminated sediments.

This study investigates how heavy metal contamination in sediments selects for plasmids carrying both metal and antibiotic resistance genes, showing co-selection through co-resistance mechanisms.

A method to correct for local alterations in DNA copy number that bias functional genomics assays applied to antibiotic-treated bacteria

The paper introduces a method to correct chromosomal location bias in functional genomics data from antibiotic-treated bacteria, improving accuracy in mutant drug sensitivity predictions.

Genomic investigation of a suspected multi-drug resistant Klebsiella pneumoniae outbreak in a neonatal care unit in sub-Saharan Africa

The paper investigates a suspected MDR K. pneumoniae outbreak using whole-genome sequencing to identify strain types and resistance genes.

SFPQ intron retention, reduced expression and aggregate formation in central nervous system tissue are pathological features of amyotrophic lateral sclerosis

This study examines SFPQ dysregulation in ALS patients, finding increased intron retention, reduced mRNA expression in motor cortex, and cytoplasmic aggregates.

Whole Genome Sequence Analysis of Shigella from Malawi Identifies Fluoroquinolone Resistance

The paper analyzes whole genome sequences of Shigella isolates from Malawi to identify fluoroquinolone resistance determinants.

Elucidating essential genes in plant-associated Pseudomonas protegens Pf-5 using transposon insertion sequencing

This study identifies essential genes in Pseudomonas protegens Pf-5 using transposon insertion sequencing, revealing differences in essentiality compared to P. aeruginosa PA14.

A global genomic approach uncovers novel components for twitching motility-mediated biofilm expansion in Pseudomonas aeruginosa

The paper uses TraDIS to identify genes involved in twitching motility-mediated biofilm expansion in Pseudomonas aeruginosa, revealing both known and novel components.