The paper identifies genetic variants associated with spontaneous coronary artery dissection using multi-trait GWAS and gene-based analysis, revealing new loci and biological pathways.

medRxiv · Mar 13, 2026 · PreprintGenetic & Genomic Medicine

Robotic Handling Preserves Induced Pluripotent Stem Cell Derived Vascular Smooth Muscle Cells Differentiation using a Weekend-free, Automatable, Low-variability, Low-cost (WALL) Protocol

Monique Bax, Jeya Ramalingam, Valentin Romanov, Muhammad A Alsherbiny, Keerat Junday, Jordan Thorpe, Emily Hurley, Melanie Lim, Ingrid S. Tarr, Stephanie Hesselson, Eleni Giannoulatou, Renjing Liu, Adam Hill, Siiri E. Iismaa, Robert M Graham

This paper develops an automated protocol for differentiating iPSC-derived vascular smooth muscle cells and shows that automation does not compromise cell quality or protein expression.

bioRxiv · Nov 25, 2025 · PreprintDevelopmental Biology

Genome-wide association meta-analysis of spontaneous coronary artery dissection reveals common variants and genes related to artery integrity and tissue-mediated coagulation

David Adlam, Takiy-Eddine Berrandou, Adrien B. Georges, Christopher P. Nelson, Eleni Giannoulatou, Joséphine Henry, Lijiang Ma, Montgomery Blencowe, Tamiel Nichole Turley, Min‐Lee Yang, Peter S. Braund, Inès Sadeg-Sayoud, Siiri E. Iismaa, Matthew Kosel, Xiang Zhou, , Nabila Bouatia‐Naji

This study identifies 17 genetic risk loci for spontaneous coronary artery dissection (SCAD), including 12 new ones, and highlights genes related to artery integrity and coagulation.

medRxiv · Jul 5, 2022 · PreprintGenetic & Genomic Medicine

SFPQ intron retention, reduced expression and aggregate formation in central nervous system tissue are pathological features of amyotrophic lateral sclerosis

Alison L. Hogan, Natalie Grima, Jennifer A. Fifita, Emily P. McCann, Benjamin Heng, Sandrine Chan Moi Fat, Sharlynn Wu, Ram Prasad Maharjan, Amy K. Cain, Lyndal Henden, Stephanie L. Rayner, Ingrid S. Tarr, Katharine Y. Zhang, Qiongyi Zhao, Zong Hong Zhang, , Ian P. Blair

This study examines SFPQ dysregulation in ALS patients, finding increased intron retention, reduced mRNA expression in motor cortex, and cytoplasmic aggregates.

Neuropathology and Applied Neurobiology · Jul 21, 2021Peer-reviewedNeuroscience