Author

Natalie Grima

Macquarie UniversityORCID 0000-0001-6434-7706Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:differential expression· 3 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Ian P. BlairiD· 4 shared Marco MorschiD· 3 shared Shu YangiD· 3 shared Albert LeeiD· 2 shared Alison L. HoganiD· 2 shared Andrew SmithiD· 2 shared Kelly L. WilliamsiD· 2 shared Lyndal HendeniD· 2 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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4 shared papersNeuroscience

Ian P. BlairORCID

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4 papers

Recent·Most cited

NeurosciencebioRxivPreprintJul 25, 2026

SFPQ dysregulation promotes TDP-43 pathology through a pathogenic feedback loop

Alison L. Hogan, Patrick Chiu, Natalie Grima…·Marco Morsch

This study identifies SFPQ as a contributor to TDP-43 pathology through a bidirectional feedback loop, showing SFPQ dysregulation drives TDP-43 mislocalization and aggregation.

DOI 10.64898/2026.07.22.740184

human

𝕏 PostBluesky

Genetic & Genomic MedicinemedRxivPreprintApr 13, 2026

Characterising the motif composition and allele length distribution of ZFHX3 GGC repeat expansions in amyotrophic lateral sclerosis

Zoe N. Zussa, Andrew Smith, Joke J.F.A. van Vugt…·Lyndal Henden

This study examines ZFHX3 GGC repeat expansions in ALS and finds no association with disease risk, but identifies diverse repeat motif compositions.

1 citation

humanwhole-genome sequencing

𝕏 PostBluesky

NeuroscienceNeuropathology and Applied NeurobiologyPeer-reviewedJul 21, 2021

SFPQ intron retention, reduced expression and aggregate formation in central nervous system tissue are pathological features of amyotrophic lateral sclerosis

Alison L. Hogan, Natalie Grima, Jennifer A. Fifita…·Ian P. Blair

This study examines SFPQ dysregulation in ALS patients, finding increased intron retention, reduced mRNA expression in motor cortex, and cytoplasmic aggregates.

25 citations

humanbulk RNA-seq

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NeurosciencebioRxivPreprintApr 30, 2020

BioID analysis of the cyclin F interactome reveals that ALS-variant cyclin F alters the homeostasis of paraspeckle-associated proteins

Stephanie L. Rayner, Flora Cheng, Shu Yang…·Albert Lee

The paper identifies cyclin F interactors using BioID and shows that ALS/FTD-associated cyclin F mutations disrupt paraspeckle protein homeostasis, particularly RBM14 levels in patient tissue.

1 citation

humanproteomics

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