Author

Melanie Spears

Ontario Institute for Cancer ResearchORCID 0000-0002-1535-4675Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell-cell communication· 2 Research Focus:clustering· 2 Organism:human· 2 Assay:spatial transcriptomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Alyona IvanovaiD· 1 shared Antonio Finelli· 1 shared Bernd BodenmilleriD· 1 shared Cristina PeñarandaiD· 1 shared Daniel P. CahilliD· 1 shared Daniel Stueckmann· 1 shared David G. MuñoziD· 1 shared Dominik DeniffeliD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Alyona IvanovaORCID

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2 papers

Recent·Most cited

Spatially resolved gene expression and tumour-microenvironment interactions across malignant transformation in IDH-mutant glioma

Alyona Ivanova, Shamini Ayyadhury, David G. Muñoz, Megan Hopkins, Farzaneh Aboualizadeh, Melanie Spears, Megan Wu, Trevor J. Pugh, Roel G.W. Verhaak, Daniel P. Cahill, Sunit Das

The paper analyzes spatial gene expression and tumor-microenvironment interactions in IDH-mutant gliomas across malignant transformation, finding reduced proliferation at the infiltrative margin in higher-grade tumors.

bioRxiv · Sep 16, 2026 · PreprintCancer Biology

Multimodal cell communication networks nominate immunotherapies for RCC subgroups with discrete T cell recruitment or expansion

Jennifer Q. Pfeil, Shirley Hui, Daniel Stueckmann, Xiaoyu Zhang, Lisa Martin, Maria Komisarenko, Jalna Meens, Jennifer L. Gorman, Julia M. Murphy, Martin L. Mak, Stéphane Chevrier, Sujana Sivapatham, Melanie Spears, Zhihui A Liu, Dominik Deniffel, , Keith A. Lawson

The paper integrates multi-modal data to identify immune subgroups in RCC and suggests immunotherapy strategies based on distinct T cell communication networks.

bioRxiv · Aug 20, 2026 · PreprintCancer Biology