Xiaoyu Zhang

Multimodal cell communication networks nominate immunotherapies for RCC subgroups with discrete T cell recruitment or expansion

The paper integrates multi-modal data to identify immune subgroups in RCC and suggests immunotherapy strategies based on distinct T cell communication networks.

Humanized patient-derived xenografts preserve tumour-specific immune microenvironments

The paper shows humanized PDX models preserve tumour-specific immune microenvironments, supporting their use for studying immune evasion mechanisms.

VIACOT: a web server for interactive visualization and comparison of cell lineage trees

VIACOT provides a web server for interactive visualization and comparison of cell lineage trees, enabling analysis of correlations and differences in cell fate across datasets.

Stereotyped cell lineage trees support robust development

The paper uses single-cell transcriptomes and lineage trees to show that sub-CLTs are stereotyped across biological replicates, indicating a robust developmental program.

HIF1A modulate glycolysis function to governs mouse ovarian microenvironment metabolic plasticity in aging single cell resolution

This study uses single-cell RNA-seq to analyze age-related changes in mouse ovarian microenvironment metabolism, identifying HIF1A's role in modulating glycolysis and other metabolic pathways.

Computational comparison of developmental cell lineage trees by alignments

This paper introduces DELTA, an algorithm for aligning developmental cell lineage trees to compare similarities in developmental programs and identify cell fate transformations and evolutionary correspondences.