Daniel P. Cahill

The paper analyzes spatial gene expression and tumor-microenvironment interactions in IDH-mutant gliomas across malignant transformation, finding reduced proliferation at the infiltrative margin in higher-grade tumors.

This study shows that inhibiting PARG enhances radiosensitivity in IDH1-mutant glioma cells by disrupting PAR-dependent replication fork processes and S-phase kinetics.

This study identifies KDM6 enzymes as targets of R2HG from mutant IDH, linking them to replication stress sensitivity in gliomas and introduces a DHODH inhibitor, GLIO-1, with potential clinical applications.

The paper identifies three distinct classes of cortical activity using high-density microelectrodes, showing they are modulated by stimuli and present across species.