Mitogen-Activated Protein Kinase-Dependent Fiber-Type Regulation in Skeletal Muscle
Justin G. Boyer, Taejeong Song, Donghoon Lee, Xing Fu, Sakthivel Sadayappan, Jeffery D. Molkentin
This study shows that sustained MEK1-ERK1/2 activity in skeletal muscle promotes a fast-to-slow fiber-type switch, suggesting potential therapeutic applications for enhancing muscle metabolic effectiveness.
bioRxiv · Mar 11, 2019 · PreprintDevelopmental Biology