Jeffery D. Molkentin

Small GTPases RhoA and RhoC coordinately regulate cardiomyocyte size in the mouse heart

This study shows RhoA and RhoC regulate cardiomyocyte size and cardiac remodeling, with compensatory effects and stress-dependent contributions to hypertrophy and function.

Deletion of cytoplasmic β/γ-actin in the mouse heart protects from disease by augmenting sarcolemma stability

This study shows deleting cytoplasmic β/γ-actin in mouse hearts improves sarcolemma stability and protects against disease under stress.

AI-based Predictive Signaling Pathway Profiling in Cardiac Fibrosis Suggests a Novel Combinatorial Treatment Strategy

The paper uses AI to analyze signaling pathways in cardiac fibrosis, identifying a dual-target treatment strategy with timed inhibition of JAK-STAT and TGF-β to reduce fibrosis without impairing acute scar formation.

Cardiomyocyte-expressed TGFβ signals to fibroblasts to program early heart maturation and adult myocyte identity

This study shows that TGFβ from cardiomyocytes programs fibroblast development and ECM environment to support cardiomyocyte maturation in the developing heart.

Atad3 is Essential for Mitochondrial Permeability Transition Pore Opening and Cardiac Ischemia Reperfusion Injury.

This study identifies ATAD3 as an essential component of the mitochondrial permeability transition pore (mPTP), showing its role in mPTP opening and reducing cardiac ischemia reperfusion injury.

Myocardial Endoglin Regulates Cardiomyocyte Proliferation and Cardiac Regeneration

The paper identifies Endoglin as an inhibitor of cardiomyocyte proliferation and shows its role in cardiac regeneration through genetic and mechanistic studies.

Loss of Acta2 in cardiac fibroblasts does not prevent myofibroblast differentiation or affect cardiac repair after myocardial infarction

S-Palmitoylation-Dependent Regulation of Cardiomyocyte Rac1 Signaling Activity and Cardiac Hypertrophy

This study identifies zDHHC3 as a critical regulator of cardiac hypertrophy by enhancing Rac1 S-palmitoylation and RhoGTPase signaling in cardiomyocytes.

Satellite cell depletion in early adulthood attenuates muscular dystrophy pathogenesis

This study shows that depleting satellite cells in dystrophic mice during early adulthood improves muscle function and reduces pathology without compromising muscle size.

Mitogen-Activated Protein Kinase-Dependent Fiber-Type Regulation in Skeletal Muscle

This study shows that sustained MEK1-ERK1/2 activity in skeletal muscle promotes a fast-to-slow fiber-type switch, suggesting potential therapeutic applications for enhancing muscle metabolic effectiveness.