BiochemistrybioRxivPreprint
A histidine-mediated, pendulum-like proton transport mechanism is required for the high catalytic activity of -hydrogenases
Jifu Duan, Yang Zhaoya, Oliver Lampret…·Thomas Happe
This study identifies a histidine-mediated pendulum mechanism in [FeFe]-hydrogenases that enhances catalytic activity by facilitating proton transfer.
DOI 10.64898/2026.09.22.753672