Author

Maria M. Flocco

AstraZeneca (United Kingdom)ORCID 0000-0002-1584-1190Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:imaging· 1

Frequent Co-Authors

Bart W. HoogenboomiD· 2 shared Mark Pailing· 2 shared Taianá Maia de OliveiraiD· 2 shared Lotte van BeekiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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2 shared papersBiophysics

Bart W. HoogenboomORCID

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintAug 30, 2025

PARP1 inhibitors regulate PARP1 structure independent of DNA, reducing binding affinity for single strand breaks

Mark Pailing, Lotte van Beek, Taianá Maia de Oliveira…·Bart W. Hoogenboom

This study shows PARP inhibitors reduce PARP1's DNA binding affinity by causing conformational changes independent of DNA, explaining similar cellular toxicities despite varying trapping potencies.

DOI 10.1101/2025.08.30.673248

experimental assay

𝕏 PostBluesky

BiophysicsNanoscalePeer-reviewedJan 1, 2025

Co2+-mediated adsorption facilitates atomic force microscopy of DNA molecules at double-helix resolution

Mark Pailing, Taianá Maia de Oliveira, Maria M. Flocco, Bart W. Hoogenboom

This paper introduces a Co2+-mediated adsorption method for DNA on mica to improve AFM imaging resolution by reducing salt precipitation compared to Ni2+.

2 citations

imagingexperimental assay

𝕏 PostBluesky