Author

Bart W. Hoogenboom

London Centre for NanotechnologyORCID 0000-0002-8882-4324Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 2 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 2 Organism:E. coli· 1 Organism:human· 1 Assay:imaging· 1 Assay:proteomics· 1

Frequent Co-Authors

Maria M. FloccoiD· 2 shared Mark Pailing· 2 shared Taianá Maia de OliveiraiD· 2 shared Adrian W. HodeliD· 1 shared Aikaterini Ellas Lemonidi· 1 shared Andrew M. EdwardsiD· 1 shared Boyan B. BoneviD· 1 shared Carolina Borrelli· 1 shared

Activity by Year

2025-2025 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersBiophysics

Maria M. FloccoORCID

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4 papers

Recent·Most cited

BiophysicsbioRxivPreprintAug 30, 2025

PARP1 inhibitors regulate PARP1 structure independent of DNA, reducing binding affinity for single strand breaks

Mark Pailing, Lotte van Beek, Taianá Maia de Oliveira…·Bart W. Hoogenboom

This study shows PARP inhibitors reduce PARP1's DNA binding affinity by causing conformational changes independent of DNA, explaining similar cellular toxicities despite varying trapping potencies.

DOI 10.1101/2025.08.30.673248

experimental assay

𝕏 PostBluesky

MicrobiologybioRxivPreprintApr 16, 2025

Polymyxin B lethality requires energy-dependent outer membrane disruption

Carolina Borrelli, Edward J. A. Douglas, Sophia M. A. Riley…·Bart W. Hoogenboom

This study shows that polymyxin B lethality requires energy-dependent outer membrane disruption and depends on metabolic activity and LPS synthesis.

DOI 10.1101/2025.04.16.649083

E. coliexperimental assay

𝕏 PostBluesky

ImmunologyEMBO ReportsPeer-reviewedJan 9, 2025

Acidic pH attenuates immune killing through inactivation of perforin

Adrian W. Hodel, Jesse A. Rudd-Schmidt, Tahereh Noori…·Ilia Voskoboinik

This study shows acidic pH inhibits perforin pore formation, reducing immune cell killing of target cells in solid tumors.

15 citationstop 4%

humanproteomics

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BiophysicsNanoscalePeer-reviewedJan 1, 2025

Co2+-mediated adsorption facilitates atomic force microscopy of DNA molecules at double-helix resolution

Mark Pailing, Taianá Maia de Oliveira, Maria M. Flocco, Bart W. Hoogenboom

This paper introduces a Co2+-mediated adsorption method for DNA on mica to improve AFM imaging resolution by reducing salt precipitation compared to Ni2+.

2 citations

imagingexperimental assay

𝕏 PostBluesky