Jaemoon Koh

Distinct Spatial Programs of Response versus Resistance in Non-Small Cell Lung Cancer after Neoadjuvant Chemoimmunotherapy

This study uses spatial transcriptomics to compare immune and metabolic differences between treatment-responsive and resistant non-small cell lung cancer tumors after neoadjuvant chemoimmunotherapy.

Fructose utilization by GM-CSF-differentiated macrophages aggravates autoimmune inflammation via MG-derived AGE-RAGE signaling

This study shows fructose metabolism in GM-CSF-differentiated macrophages promotes autoimmune inflammation through MG-AGE-RAGE signaling by enhancing glycolysis and Th17 differentiation.

Graft-Induced Reprogramming Under Arterial Hemodynamic Stress is Associated with a Shared Proteomic Phenotype in Arterial and Venous Conduits Following Coronary Artery Bypass Grafting

This study identifies a shared adaptive proteomic phenotype in successful arterial and venous coronary bypass grafts, contrasting with fibroinflammatory remodeling in failed venous grafts.

Spatial Transcriptomics Reveals Spatially Diverse Cancer-Associated Fibroblast in Lung Squamous Cell Carcinoma Linked to Tumor Progression

This study uses spatial transcriptomics to analyze cancer-associated fibroblasts in lung squamous cell carcinoma, linking their spatial organization to tumor progression and patient outcomes.

CellDART: Cell type inference by domain adaptation of single-cell and spatial transcriptomic data

CellDART adapts neural networks to infer cell type spatial distribution from single-cell and spatial transcriptomic data, showing effectiveness in human and mouse tissues.