The paper shows that Snord116 regulates Nhlh2 mRNA localization, with loss of Snord116 causing cytoplasmic Nhlh2 mRNA in hypothalamic neurons, impacting Prader-Willi Syndrome.

bioRxiv · Jan 23, 2026 · PreprintNeuroscience

Sex specific effects of environmental toxin-derived alpha synuclein on enteric neuronal-epithelial interactions

Hayley Templeton, Alexis Ehrlich, Luke Schwerdtfeger, Julietta A. Sheng, Ronald B. Tjalkens, Stuart A. Tobet

This study investigates sex-specific effects of environmental toxin-derived alpha synuclein on enteric neuronal-epithelial interactions in a mouse model of Parkinson's Disease, finding increased aSyn and CGRP immunoreactivity in females.

Neurogastroenterology & Motility · Apr 24, 2025Peer-reviewedPhysiology

Prenatal Dexamethasone Programs Autonomic Dysregulation in Female Rats

Lakshmi Madhavpeddi, Monique Martinez, Jared Alvarez, Arpan Sharma, Chengcheng Hu, Stuart A. Tobet, Taben Mary Hale

This study shows that prenatal dexamethasone exposure in female rats leads to autonomic dysregulation, characterized by reduced parasympathetic influence and increased sympathetic responses to stress.

American Journal of Physiology-Heart and Circulatory Physiology · Dec 24, 2024Peer-reviewedPhysiology

Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders

Gabriëlla A.M. Blokland, Jakob Grove, Chia‐Yen Chen, Chris J. Cotsapas, Stuart A. Tobet, Robert J. Handa, Stephan Ripke, Benjamin M. Neale, Aiden Corvin, James Walters, Kai-How Farh, Peter Holmans, Phil Lee, Brendan K Bulik-Sullivan, David Andrew Collier, , Joel N. Hirschhorn

This study identifies sex-dependent genetic risk loci shared and specific to mood and psychotic disorders using genome-wide interaction analysis.

Biological Psychiatry · Jan 1, 2022Peer-reviewedGenetics