Impaired bone strength and bone microstructure in a novel early-onset osteoporotic rat model with a clinically relevant PLS3 mutation
Jing Hu, Bingna Zhou, Xiaoyun Lin, Qian Zhang, Feifei Guan, Lei Sun, Jiayi Liu, Ou Wang, Yan Jiang, Weibo Xia, Xiaoping Xing, Mei Li
This study creates a novel rat model with a PLS3 mutation to study early-onset osteoporosis and finds that alendronate and teriparatide improve bone strength and microstructure.
eLife · Apr 21, 2023Peer-reviewedGenetics