Jiayi Liu

This study examines how different SETD1A mutations and genetic backgrounds affect human hippocampal neurons derived from hiPSCs, revealing divergent molecular and cellular phenotypes and contrasting mutation impacts.

ExSPM reveals spatiotemporal heterogeneities in lipid droplet polarity, showing dynamics and pathway-specific kinetics of lipid metabolism.

This study examines how polygenic risk scores for Alcohol Use Disorder affect microglial responses to ethanol exposure in human iPSC-derived microglia.

This study investigates how rare mutations in the SETD1A gene affect human neurons, showing they disrupt synaptic function and may contribute to schizophrenia pathophysiology.

This paper evaluates sequence design strategies for perturbation MPRA using a computational framework and finds that random nucleotide shuffling outperforms other methods.

PhylinSic reconstructs phylogenetic relationships from scRNA-seq data to model tumor evolution and identify subclones and lineage-specific gene expression patterns.

This study creates a novel rat model with a PLS3 mutation to study early-onset osteoporosis and finds that alendronate and teriparatide improve bone strength and microstructure.