Molecular basis of mitochondrial leucine transport by human Sideroflexin 1
Fiona Fitzpatrick, Daniel T.D. Jones, Hannah Aguirre, Benjamin N. Fry, Elena T. Kaemmerer, S. Tan, Luise E. Veelken, Wen Han Tong, Samuel Block, S. Ali Aghvami, Edmund R.S. Kunji, Nicholas F. Polizzi, Stephen C. Blacklow, Nora Kory
The paper identifies leucine as the substrate for SFXN1 and reveals its alternating-access transport mechanism using structural and biochemical analyses.
bioRxiv · Aug 21, 2026 · PreprintMolecular Biology