Samuel Block

The paper identifies Sfxn1-3's role in regulating mitochondrial volume during the egg-to-embryo transition by controlling amino acid export and osmotic balance.

The paper identifies leucine as the substrate for SFXN1 and reveals its alternating-access transport mechanism using structural and biochemical analyses.

This study shows that α-ketoacids enhance the effectiveness of bortezomib by reducing cysteine-mediated detoxification, thereby increasing proteasome inhibition and cytotoxicity.

This study shows that dietary cysteine improves intestinal stem cell repair through IL-22 from CD8+ T cells.

This study shows that inhibiting formate production in CD8+ T cells delays type 1 diabetes onset in mice by reducing their activation and effector function.

The paper identifies sideroflexins as mitochondrial transporters for neutral amino acids and shows functional overlap among paralogues.

The paper identifies PRDX1 as essential for DNA damage repair by scavenging nuclear ROS and regulating aspartate synthesis during the DNA damage response.

This study identifies TES-1 as a protein that stabilizes junctional actin networks during cell shape changes in C. elegans embryos by preventing self-injury under tension.