The MS4A gene cluster is a key regulator of soluble TREM2 and Alzheimer disease risk
Yuetiva K. Deming, Fabia Filipello, Francesca Cignarella, Claudia Cantoni, Simon Hsu, Robert J. Mikesell, Zeran Li, Jorge L. Del‐Aguila, Umber Dube, Fabiana Geraldo Farias, Joseph L. Bradley, Bruno Benitez, John Budde, Laura Ibañez, Maria Victoria Fernandez, , Carlos Cruchaga
This study identifies genetic variants in the MS4A gene cluster associated with higher sTREM2 levels and reduced Alzheimer disease risk, suggesting MS4A4A regulates sTREM2 and contributes to AD pathogenesis.
Science Translational Medicine · Aug 14, 2019Peer-reviewedGenomics