Author

Francesca Cignarella

Alector (United States)ORCID 0000-0003-0342-5699Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:experimental assay· 1 Research Focus:GWAS / association mapping· 1 Organism:non-human primate· 1 Approach:statistical model· 1

Frequent Co-Authors

Adiljan Ibrahim· 1 shared Alberto LleóiD· 1 shared Alice BuonfiglioliiD· 1 shared Alzheimer’s Disease Neuroimaging Initiative· 1 shared Amanda HeslegraveiD· 1 shared Ananya MitraiD· 1 shared Angie Yee· 1 shared Anna Rychkova· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperNeuroscience

Adiljan Ibrahim

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2 papers

Recent·Most cited

NeuroscienceNeuronPeer-reviewedDec 22, 2025

The Alzheimers Disease Risk Genes MS4A4A And MS4A6A Cooperate to Negatively Regulate Trem2 and Microglia states

Dalya Rosner, Jiahong Sun, Rita Cacace…·Arnon Rosenthal

This study shows that MS4A4A and MS4A6A negatively regulate TREM2 and microglial function in Alzheimer's disease, suggesting they are potential drug targets.

17 citationstop 3%

humannon-human primate

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GenomicsScience Translational MedicinePeer-reviewedAug 14, 2019

The MS4A gene cluster is a key regulator of soluble TREM2 and Alzheimer disease risk

Yuetiva K. Deming, Fabia Filipello, Francesca Cignarella…·Carlos Cruchaga

This study identifies genetic variants in the MS4A gene cluster associated with higher sTREM2 levels and reduced Alzheimer disease risk, suggesting MS4A4A regulates sTREM2 and contributes to AD pathogenesis.

270 citationstop 1%

humanstatistical model

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