Amanda Heslegrave

The paper investigates infraslow oscillations (ISO) in sleep and their potential link to Alzheimer's disease by analyzing EEG data and correlating ISO metrics with biomarkers.

This study shows that the Gars{Delta}ETAQ mutation in mice causes specific peripheral nerve pathology in motor and sensory neurons, affecting multiple functions and providing a model for CMT2D research.

The paper identifies grey matter microstructural changes in Lewy body diseases using diffusion MRI metrics, finding increased tODI and FWF linked to cognitive impairment and p-tau217 levels.

The paper identifies novel APP transcripts that generate Aβ independently of β-secretase, showing their expression and presence in CSF.

The paper compares neuroimaging and plasma biomarkers in Lewy body dementia subtypes, finding differences in white matter integrity and plasma markers between dementia with Lewy bodies and Parkinson's disease dementia.

The paper shows impaired glymphatic clearance is linked to poor outcomes in Parkinson's disease, with distinct effects on brain structure and iron distribution.

This study detects neurodegenerative biomarkers in human cervical lymph nodes, showing higher concentrations than plasma and age-related changes in phospho-Tau-181.

This study uses high-dimensional proteomic analysis to identify TBI-specific plasma protein changes linked to injury patterns and pathophysiology in humans.

The paper shows that white matter macrostructure loss and elevated plasma neurofilament light chain levels are associated with poor outcomes in Parkinson's disease.

This study investigates the association between Klotho heterozygosity and Alzheimer's disease risk in APOE4 carriers using multiple AD endophenotypes from large cohorts.

This study shows that higher plasma phospho-tau181 levels and their increase over time predict faster cognitive decline in older adults and are present in brain synapses.

The paper analyzes plasma A{beta} ratios in ADAD mutation carriers and non-carriers, finding significant differences between PSEN1 and APP carriers and associations with parental age at onset.

This study identifies genetic variants in the MS4A gene cluster associated with higher sTREM2 levels and reduced Alzheimer disease risk, suggesting MS4A4A regulates sTREM2 and contributes to AD pathogenesis.

The paper measures plasma pNfH levels in SBMA and ALS patients, finding no increase in SBMA but a significant increase in ALS, suggesting pNfH could differentiate the two diseases.

This study shows that neurofilament light (NF-L) levels in blood increase with age and predict dementia in adults with Down syndrome, suggesting its potential as a non-invasive biomarker for neurodegeneration.