Zeran Li

Genomic and multi-tissue proteomic integration for understanding the biology of disease and other complex traits

The paper integrates genomic and proteomic data across multiple tissues to identify protein quantitative loci (pQTL) and their implications for neurodegenerative diseases.

The MS4A gene cluster is a key regulator of soluble TREM2 and Alzheimer disease risk

This study identifies genetic variants in the MS4A gene cluster associated with higher sTREM2 levels and reduced Alzheimer disease risk, suggesting MS4A4A regulates sTREM2 and contributes to AD pathogenesis.

A single- nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain

This study uses single-nuclei RNA-seq to compare cell proportions and gene expression in Mendelian and sporadic AD brains, identifying reduced excitatory neurons in a Mendelian carrier and proposing best practices for analysis.

The TMEM106B rs1990621 protective variant is also associated with increased neuronal proportion

The paper identifies a genetic variant in TMEM106B associated with increased neuronal proportion in neurodegenerative and cognitive normal cohorts, suggesting a role in neuronal protection.

Analysis of whole genome-transcriptomic organization in brain to identify genes associated with alcoholism

The paper identifies 129 differentially expressed genes in the PFC of alcoholics and links them to pathways and modules associated with alcohol dependence and consumption.

Genetic variants associated with Alzheimer's disease confer different cerebral cortex cell-type population structure

This study identifies how genetic risk variants for Alzheimer's disease affect cerebral cortex cell-type proportions in bulk RNA-seq data using digital deconvolution.