Farrah El-Saafin

This study uses genetic barcoding to analyze clonal composition in solid and liquid biopsies of breast cancer models, revealing differences in clonal diversity and DNA shedding patterns.

The paper identifies neurogenesis-related gene expression as a clone-specific hallmark of brain metastasis in breast cancer using a new optical barcoding tool.

This study shows that USP22 and ATXN7L3 are essential for mouse development, with distinct roles, and that H2Bub1 deubiquitylation does not globally regulate RNA polymerase II transcription.

The paper shows that mammalian nuclear transcription complexes assemble co-translationally, with dimerization domains dictating the assembly pathway.