Tao Ye

This study shows that satellite cell glucocorticoid receptor (GR) maintains quiescence but does not mediate therapeutic GC effects on muscle repair, highlighting the importance of treatment timing and context.

This study shows that androgen receptor signaling regulates beige adipocyte remodeling, mitochondrial function, and metabolic adaptation in male mice.

This study compares cell-cycle gene expression dynamics and mRNA kinetics across mouse and human pluripotent systems, revealing species-specific differences in transcriptional complexity and oscillatory control.

This study shows that glucocorticoid receptor (GR) interacts with androgen receptor (AR) to regulate prostate epithelial homeostasis through shared cis-regulatory elements.

The paper identifies CHD1L as a key regulator of neurodevelopmental processes, showing its role in shaping neuroanatomical and growth phenotypes linked to 1q21.1 copy number variants.

The paper uses single-cell multiomics to analyze mRNA metabolism and chromatin accessibility dynamics during the cell cycle, revealing oscillatory patterns and regulatory mechanisms.

This study shows novel synthetic ecteinascidins effectively treat melanoma by inhibiting super-enhancer-driven oncogenic transcription, even in resistant models.

This study shows that reduced RARβ signaling in HD mouse models accelerates motor and transcriptional abnormalities, suggesting a protective role for RARβ in disease progression.

This study shows that reducing DHFR activity in neural progenitors accelerates indirect neurogenesis and alters neuronal composition in human and mouse neocortex.

The paper identifies a novel FTSJ1 pathogenic variant and shows its role in neuron morphology and learning performance through RiboMethSeq and transcriptome analysis in human and Drosophila models.

This study identifies the dual role of sumoylation in adipocyte differentiation by regulating gene expression and transcriptional network rewiring through SLAMseq and ChIPseq.

This study maps NEUROG3 occupancy in human pancreatic endocrine progenitors, identifying 1268 target genes and linking NEUROG3 to islet cell development and type 2 diabetes risk variants.

This study shows that USP22 and ATXN7L3 are essential for mouse development, with distinct roles, and that H2Bub1 deubiquitylation does not globally regulate RNA polymerase II transcription.

The paper shows that the TBPL2/TFIIA complex establishes the oocyte transcriptome by using a specific TSS recognition code through oocyte-specific promoter usage.