Jaya Srivastava

The paper identifies enhancers prone to regulatory turnover using deep learning and shows they are repurposed between cell types, especially near neurodevelopmental genes.

The paper identifies sequence motifs near the pyranose binding site that confer reaction specificity in fold type I aminotransferases, enabling classification of their substrate specificity.

The paper discusses methods to customize functional homolog searches using profile HMMs and evaluates bit score thresholds through case studies.

GlycoPathDB compiles experimentally characterized monosaccharide biosynthesis pathways and enzymes, providing annotations and sequence homologs for evolutionary and functional studies.

The paper hypothesizes that the glycan alphabet is not universal, showing variation in monosaccharide biosynthesis pathways across bacterial and archaeal genomes.