Author

Elizabeth M. Sachse

University of MinnesotaORCID 0000-0002-1669-8752Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:rat· 4 Assay:electronic health records· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Approach:Bayesian inference· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Alik S. WidgeiD· 5 shared Evan M. Dastin-van RijniD· 5 shared Megan E. MensingeriD· 4 shared Jonathan P Bennek· 3 shared Michelle C. BucciniiD· 3 shared Adriano E. ReimeriD· 2 shared Bradley AngstadtiD· 2 shared Francesca A. Iacobucci· 2 shared

Activity by Year

2022-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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5 shared papersNeuroscience

Alik S. WidgeORCID

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Unilateral striatal deep brain stimulation improves cognitive control

Elizabeth M. Sachse, Evan M. Dastin-van Rijn, Jonathan P Bennek, Michelle C. Buccini, Megan E. Mensinger, Francesca A. Iacobucci, Adriano E. Reimer, Alik S. Widge

This study shows unilateral striatal deep brain stimulation improves cognitive control similarly to bilateral stimulation in rodents, matching human findings and highlighting potential clinical benefits.

Journal of Neuroscience · Jun 18, 2026Peer-reviewedNeuroscience

Prefrontal cortical pathways mediating cognitive control enhancement from internal capsule stimulation

Karianne Sretavan Wong, Sumedh Sopan Nagrale, Victoria L Pipia, Elizabeth M. Sachse, Evan M. Dastin-van Rijn, Jaejoong Kim, Spencer Eiting, Aaron N. McInnes, Tara Palnitkar, Jayashree Chandrasekaran, Henry Braun, Samuel Brenny, Yasamin Seddighi, Rémi Patriat, Noam Harel, , Alik S. Widge

This study identifies right dorsal prefrontal cortical pathways mediating cognitive control improvements from VCVS DBS.

bioRxiv · Jun 9, 2026 · PreprintNeuroscience

mPFC axons drive cognitive control enhancement during striatal stimulation

Elizabeth M. Sachse, Evan M. Dastin-van Rijn, Jonathan P Bennek, Michelle C. Buccini, Megan E. Mensinger, Bradley Angstadt, Francesca A. Iacobucci, Manuel Esguerra, Alik S. Widge

This study shows that optogenetic stimulation of mPFC axons, not midSTR neurons, enhances cognitive control in a rodent Set-Shift task, suggesting mPFC axons are key drivers of DBS therapeutic effects.

bioRxiv · Apr 8, 2026 · PreprintNeuroscience

Real-time Bayesian optimization of deep brain stimulation for personalized cognitive control enhancement

Evan M. Dastin-van Rijn, Elizabeth M. Sachse, Michelle C. Buccini, Bradley Angstadt, Jonathan P Bennek, Megan E. Mensinger, Alik S. Widge

This study uses Bayesian Optimization to find optimal DBS parameters in rats for improving cognitive control, showing consistent effects across acute and chronic settings.

bioRxiv · Dec 30, 2025 · PreprintNeuroscience

Cross-species modeling and enhancement of cognitive control with striatal brain stimulation

Adriano E. Reimer, Evan M. Dastin-van Rijn, Jaejoong Kim, Megan E. Mensinger, Elizabeth M. Sachse, Aaron Wald, Eric Hoskins, Kartikeya Singh, Abigail Alpers, Dawson Cooper, Meng-Chen Lo, Amanda Ribeiro de Oliveira, Gregory J. Simandl, Nathaniel Stephenson, Alik S. Widge

The paper develops an animal model of human brain stimulation therapy, showing it enhances cognitive control by improving the brain's ability to process conflicting evidence.

bioRxiv · Feb 16, 2024 · PreprintNeuroscience

Dynamic attention signaling in V4: relation to excitatory/inhibitory cell class and population coupling

Elizabeth M. Sachse, Adam C. Snyder

The paper investigates how attention affects neurons in V4, finding differences in attention effects based on neuron type and functional connectivity.

bioRxiv · Aug 3, 2022 · PreprintNeuroscience