Brittany F. Karas

This study examines the impact of maternal compensation on developmental phenotypes in a zebrafish model of congenital muscular dystrophy, showing distinct effects between zygotic and maternal-zygotic knockouts.

This study shows that removing pomt1 in zebrafish leads to dystroglycanopathy phenotypes, including muscle disease and retinal defects, and highlights the role of maternal pomt1 mRNA in development.

The paper shows that zebrafish inpp5ka and inpp5kb, duplicated from whole genome duplication, have diverged in expression and function, with inpp5ka more closely related to human INPP5K and inpp5kb losing catalytic activity.