Pharmacology & ToxicologyChemical Research in ToxicologyPeer-reviewed
Aetokthonotoxin, the causative agent of vacuolar myelinopathy, uncouples oxidative phosphorylation due to protonophore activity
Valerie I. C. Rebhahn, Mohamad Saoud, Mathias Winterhalter…·Timo H. J. Niedermeyer
This study identifies Aetokthonotoxin as a protonophore that uncouples oxidative phosphorylation, leading to ATP depletion and neurotoxic effects in wildlife.